I have about 26 miles to go delivering goods on level 15. I've clicked on the destination city and...nothing. The green cursor box has appeared around the city, and the train is just sitting in its present city. The rest of the game's UI is responsive - I can mouse over things and get popups, get help, even return to the main menu and come back into the game - but the game itself is stalled.
If I exit the program completely and come back in, I start level 15 over again. And again, at the end, it locks up in exactly the same way.
